條理清楚，擺事實、講道理
語言簡單、平實、明確、直接
容易被理解和接受
正確、準確地使用英語
vetral/ventricle; casual/causal
用最少、最短的詞
科學論文的基本結構
Introduction, Methods, Results, and Discussion (IMRAD)
I: What and why? 研究什么問題？為什么研究這個問題？
M：How? 如何研究的？
R：What? 發現了什么？
D：What? 發現意味著什么？
標 題
重要性
體現創新點
包含所有關鍵詞 （檢索）
吸引人
用動詞、句子
采用動詞（1）
Hippocampal long-term potentiation is reduced by chronic opiate
treatment and can be restored by re-exposure to opiates. J. Neurosci.
Heterologous activation of protein kinase C stimulates phosphorylation
of d-opioid receptor at serine 344 and this results in b-arrestin- and
clathrin-mediated receptor internalization. J Biol Chem
Anti-HIV agent trichosanthin enhances the capabilities of chemokines
to stimulate chemotaxis and G protein activation and this is mediated
through interaction of trichosanthin and chemokine receptor. J Exp Med
采用動詞（2）
Divalent cations and ligands induce conformational changes that
are highly divergent among b1 integrins. J Biol Chem
Inhibition of CamK II in rat hippocampus attenuates morphine
tolerance and dependence. Mol Pharmacol.
Chemokine receptor CCR5 functionally couples to inhibitory G
proteins and undergoes desensitization. J Cell Biochem
Carboxyl terminus of delta opioid receptor is required for
agonist-dependent receptor phosphorylation. Biochem Biophys Res Commun
采用動詞（3）
N-methyl-D-aspartate attenuates opioid receptor-mediated G
protein activation and this process involves protein kinase C.
Mol Pharmacol.
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation
and activation of p38 MAPK in NG108-15 cells and this is regulated
by protein kinase A and protein kinase C. J Neurochem
Activation of N-methyl-D-aspartate receptor attenuates acute
responsiveness of delta-opioid receptors. Mol Pharmacol
Cholecystokinin-B receptor antagonists attenuate morphine
dependence and withdrawal in rats. Neuroreport
采用詞組
Identification of G protein-coupled receptor kinase 2
phosphorylation sites responsible for agonist-stimulated
delta-opioid receptor phosphorylation. Mol Pharmacol
Differential roles of corticotropin-releasing factor
receptor subtypes 1 and 2 in opiate withdrawal and in
relapse to opiate dependence.
Identification of a human brain-specific isoform of mammalian
STE20-like kinase 3 that is regulated by cAMP-dependent
protein kinase. J Biol Chem
Selective interference of b-arrestin 1 with k and d but not
m opioid receptor/G protein coupling. J Biol Chem.
Differential and tissue-spesific expression of mitochondrial
elongation factor Tu and Ts during development. Acta Bioch Bioph Sin
Differential efficacies of k agonists to induce homologous
desensitization of k opioid receptor. Neurosci Lett
采用詞組（冒號）
Reactivation of morphine conditioned place preference by
drug priming: role of environmental cues and sensitization.
Psychopharmacology
Five-transmembrane domain structure is sufficient for a
G protein coupled receptor: Functional five-transmembrane
domain chemokine receptors. Proc Natl Acad Sci USA.
Etorphine inhibits cell growth and induces apoptosis in
SK-N-SH cells: involvement of pertussis toxin-sensitive
G proteins. Neurosci Res
Retardation of pain development: a case of recovery from
congenital insensitivity to pain. Acta Anaesthesiol Scand
類似的研究（1）
Differential regulation of beta-arrestin 1 and beta-arrestin
2 gene expression in rat brain by morphine. Neuroscience
Acute and chronic morphine treatments and morphine withdrawal
differentially regulate GRK2 and GRK5 gene expression in rat
brain. Neuropharmacology
類似的研究（2）
Direct and differential interaction of beta-arrestins with
the intracellular domains of different opioid receptors. Mol Pharmacol
Direct binding of beta-arrestins to two distinct intracellular
domains of the delta opioid receptor. J Neurochem
類似的研究（3）
Functional expression, activation and desensitization of opioid
receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15
hybrid cells. FEBS Lett
Endogenous opioid receptor-like receptor in human neuroblastoma
SK-N-SH cells: activation of inhibitory G-protein and homologous
desensitization. Neuroreport
Not so good (1)
Mechanistic studies of the translational elongation cycle in
mammalian mitochondria. Biochim Biophys Acta
Molecular characterization and functional expression of opioid
receptor-like receptor. Cell Res.
Functional expression of opioid receptor-like receptor and its
endogenous specific agonist nociceptin/orphanin FQ during embryogenesis. Cell Res
